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KMID : 0391520170250040246
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Journal of the Korean Child Neurology Society
2017 Volume.25 No. 4 p.246 ~ p.254
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Clinical Features and Neurologic Complications of Pediatric Enteroviral Meningitis
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Choi Seo-Yeol
Lee Young-Seok
Yu Jee-Suk
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Abstract
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Purpose: To explore clinical features and neurologic complications of pediatric enteroviral meningitis, and to evaluate risk factors according to the presence of cerebrospinal fluid (CSF) pleocytosis and neurologic complications.
Methods: Retrospective review of medical records of patients aged between 1 month and 18 years who were found positive for CSF enterovirus reverse transcription polymerase chain reaction in Dankook University Hospital from March 2009 to February 2015.
Results: A total of 151 children was enrolled in the study. Ninety four patients were males and the age at diagnosis was 40.9±47.0 months. Most common season of admission was summer (n=99, 65.6%). Most frequent presenting symptom was fever followed by poor oral intake, decreased activity, and headache. Fifty five (36.4%) patients had no CSF pleocytosis. Complications were observed in 4 (2.6%). Mean blood white blood cell, CSF protein levels were higher, and CSF glucose levels were lower in group with pleocytosis (P<0.05). There were more seizure development and mental changes, higher peak body temperature, longer fever duration, and longer duration from symptom onset to CSF tapping in group with complications (P<0.05). All were boys and mean age at admission was younger in group with complications, without statistically significant difference.
Conclusion: Relatively high proportion of children with enteroviral meningitis showed no pleocytosis. Complications such as meningoencephalitis, refractory status epilepticus, or recurrent seizure rarely occurred, although most had good clinical outcomes.
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KEYWORD
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Enterovirus, Meningitis, Pleocytosis, Complication
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